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KMID : 0358320110520080507
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Korean Journal of Urology
2011 Volume.52 No. 8 p.507 ~ p.516
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Metabolic Syndrome and Benign Prostatic Hyperplasia: Evidence of a Potential Relationship, Hypothesized Etiology, and Prevention
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Abdollah Firas
Briganti Alberto
Suardi Nazareno
Castiglione Fabio
Gallina Andrea
Capitanio Umberto
Montorsi Francesco
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Abstract
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Benign prostatic hyperplasia (BPH) is highly prevalent in older men and causes substantial adverse effects on health. The pathogenesis of this disease is not totally clear. Recent reports have suggested a possible relationship between metabolic syndrome (MetS) and BPH. Single components of MetS (obesity, dyslipidemia, hypertension, and insulin resistance) as well as the syndrome itself may predispose patients to a higher risk of BPH and lower urinary tract symptoms (LUTS). This may stem from changes in insulin resistance, increased autonomic activity, impaired nitrergic innervation, increased Rho kinase activity, pro-inflammatory status, and changes in sex hormones that occur in association with MetS. However, the exact underlying mechanisms that regulate the potential relationship between MetS and BPH/LUTS still need to be clarified. Increased physical activity and dietary strategies may help in decreasing the incidence of MetS and its impact on BPH/LUTS. However, differences in the definitions used to address the examined predictors and endpoints preclude the possibility of arriving at definitive conclusions.
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KEYWORD
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Insulin resistance, Metabolic syndrome X complications, Obesity complications, Prostatic hyperplasia etiology, Prostatic hyperplasia pathology
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